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Updated: Jun 6, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Association of vascular endothelial growth factor -2578C/A gene polymorphism in Chinese patients with colon cancer
Lin Zhang1, Guohu Zhang, Peihong Wang
1Center of General Surgery, Chengdu General Hospital of Chengdu Military Area Command, Chengdu, China.
Abstract:
The vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in the process of angiogenesis, a crucial phase in tumor growth and metastasis. We carried out a case-control study to evaluate whether VEGF -2578C/A gene polymorphism modulates the risk of developing colon cancer. A total of 110 colon cancer patients and 110 cancer-free healthy people were recruited in the Chinese population. Genomic DNA was isolated from peripheral blood, and gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Colon cancer patients had a significantly higher frequency of VEGF -2578AA genotype (odds ratio=2.49; 95% confidence interval=1.04, 6.01; p=0.04) than controls. Patients with left colon cancer had a significantly higher frequency of VEGF -2578AA genotype (odds ratio=2.31; 95% confidence interval=1.03, 5.18; p=0.04) than those with right colon cancer. When stratified by tumor size, growth pattern, differentiation, and stage of colon cancer, no statistically significant results were observed. This study suggested that VEGF -2578AA genotype was associated with a higher risk of colon cancer in Chinese population. Further studies are needed to understand the mechanism of VEGF gene polymorphisms in the development and progression of colon cancer.
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