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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 6, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

pH-sensitive PEG-based micelles for tumor targeting.

Stefano Salmaso1, Sara Bersani, Marco Pirazzini

  • 1Department of Pharmaceutical Sciences, University of Padova, Padova, Italy. stefano.salmaso@unipd.it

Journal of Drug Targeting
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

New pH-sensitive lipid-core micelles, using Sulfadimethoxine-PEG-phospholipid (SD-PEG-DSPE), enhance tumor drug delivery. These nanocarriers show increased cell uptake and paclitaxel delivery at acidic tumor pH levels.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Tumor microenvironments often exhibit acidic pH.
  • Targeted drug delivery systems require efficient tumor cell interaction.
  • pH-responsive nanocarriers can improve therapeutic efficacy.

Purpose of the Study:

  • To develop and characterize a novel acid-sensitive nanocarrier for tumor-targeted drug delivery.
  • To evaluate the pH-responsive behavior of Sulfadimethoxine-PEG-phospholipid (SD-PEG-DSPE) micelles.
  • To assess the efficiency of paclitaxel delivery and cellular uptake at different pH values.

Main Methods:

  • Synthesis and characterization of SD-PEG-DSPE unimers.
  • Micelle formation, critical micelle concentration, and size analysis.
  • Drug loading and release studies of paclitaxel.
  • Cellular association, uptake, and cytotoxicity assays using MCF7 cells at varying pH.

Main Results:

  • SD-PEG-DSPE unimers formed stable 20 nm micelles with a pKa of 6.7.
  • Micelles exhibited efficient paclitaxel loading and sustained release.
  • Enhanced cellular association and uptake of micelles were observed at acidic pH (6.2) compared to neutral pH (7.4).
  • Increased cytotoxicity of paclitaxel delivered by micelles was confirmed at pH 6.2.

Conclusions:

  • SD-PEG-DSPE based lipid-core micelles are effective pH-sensitive nanocarriers for tumor-targeted drug delivery.
  • The acidic tumor environment can trigger enhanced cellular internalization and drug delivery.
  • This nanocarrier system holds promise for improving cancer therapy outcomes.