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Updated: Feb 12, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
The relationship between inflammation, platelet activation and antiplatelet resistance
Sadik Acikel1, Ramazan Akdemir
1Ministry of Health Dişkapı Yildirim Beyazit Research and Educational Hospital, Department of Cardiology, 06110 Ankara, Turkey. sadik.acikel@tkd.org.tr
Abstract:
Even though there is a strong evidence suggestive of benefits and safety of dual (aspirin plus clopidogrel) antiplatelet therapy, decreased responsiveness or "resistance" to mono- and/or dual antiplatelet therapy has been described in association with an increased thrombotic risk. Various mechanisms contribute to antiplatelet resistance, with abundant production of inflammatory markers being of particular importance. The current review overviews implications of inflammation in antiplatelet resistance.
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