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Tumor necrosis factor alpha and interferon gamma inhibit proliferation and alkaline phosphatase activity of human
R Yoshihara1, S Shiozawa, Y Imai
1Department of Medicine, Kobe University, Japan.
Lymphokine Research
|January 1, 1990
Abstract:
Tumor necrosis factor (TNF) alpha and TNF beta both inhibited proliferation of cultured human osteoblastic SaOS-2 cells. TNF alpha also inhibited alkaline phosphatase (ALP) activity in the cells. The TNF alpha-induced inhibition of proliferation and ALP activity was further potentiated by interferon (IFN) gamma. These findings indicate that human SaOS-2 cells, fulfilling several criteria for osteoblasts, respond to TNF alpha and IFN gamma, resulting in decceleration of their maturation.