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Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
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Biosynthesis of Lipids01:29

Biosynthesis of Lipids

Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

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Updated: Jun 6, 2026

Lipid Index Determination by Liquid Fluorescence Recovery in the Fungal Pathogen Ustilago Maydis
10:22

Lipid Index Determination by Liquid Fluorescence Recovery in the Fungal Pathogen Ustilago Maydis

Published on: April 3, 2018

Lipid signalling in pathogenic fungi.

Arpita Singh1, Maurizio Del Poeta

  • 1Biochemistry and Molecular Biology Microbiology and Immunology Division of Infectious Diseases, Medical University of South Carolina, Charleston, SC 29425, USA.

Cellular Microbiology
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Lipid signaling in microbes, including yeasts and moulds, is crucial for fungal pathogenicity and virulence. Key molecules like sphingolipids and farnesol regulate fungal growth, stress responses, and immune evasion.

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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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Lipid Index Determination by Liquid Fluorescence Recovery in the Fungal Pathogen Ustilago Maydis
10:22

Lipid Index Determination by Liquid Fluorescence Recovery in the Fungal Pathogen Ustilago Maydis

Published on: April 3, 2018

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Area of Science:

  • Microbiology
  • Molecular Biology
  • Biochemistry

Background:

  • Lipid signaling, extensively studied in mammals, is increasingly recognized in microbial systems.
  • Microbial lipid signaling networks are vital for fungal pathogenicity and virulence.
  • Sphingolipids and quorum sensing molecules (QSMs) are key players in fungal biology.

Purpose of the Study:

  • To review the role of lipid signaling in microbial cells, focusing on yeasts and moulds.
  • To detail the involvement of sphingolipids, QSMs, and oxylipins in fungal pathogenicity and host immune response.

Main Methods:

  • Literature review of studies on lipid signaling in fungi.
  • Analysis of the roles of specific lipid molecules (sphingolipids, farnesol, oxylipins) in fungal virulence.

Main Results:

  • Microbial sphingolipids and their enzymes regulate pathogenicity in fungi like Cryptococcus neoformans.
  • Farnesol (a QSM) influences Candida albicans growth, biofilm formation, and stress responses.
  • QSMs and sphingolipids are essential for Aspergillus fumigatus cell wall integrity and virulence.
  • Fungal oxylipins enhance virulence and aid in counteracting host immune defenses.

Conclusions:

  • Lipid signaling networks are critical determinants of fungal virulence and host-pathogen interactions.
  • Understanding these pathways offers potential targets for antifungal strategies.