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Updated: Jun 6, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
Riccardo Dolcetti1, Antonino Carbone
1Cancer Bio-Immunotherapy Unit, CRO - IRCCS, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano, Italy. rdolcetti@cro.it.
Abstract:
Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lymphocytic leukemia (CLL) and EBV infection has been also associated with Richter transformation in a fraction of cases. We herein review available data suggesting a possible role of EBV as a direct or micro-environmental progression factor in a subset of CLL.
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