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[Effect of FAM172A protein on apoptosis and proliferation in HEK293 cells]

Lian-xi Li1, Wen-bai Zhou, Zheng Tao

  • 1Department of Endocrinology & Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai key Laboratory of Diabetes Mellitus, Shanghai 200233, China.

Zhonghua Yi Xue Za Zhi
|November 25, 2010
PubMed
Abstract

Insights

The FAM172A protein enhances cell proliferation and inhibits apoptosis in HEK293 cells, suggesting a role in regulating cell growth. This protein may be involved in the development of diabetic macroangiopathy.

Area of Science:

  • Molecular Biology
  • Cell Biology

Context:

  • Diabetic macroangiopathy is a serious complication of diabetes mellitus.
  • The FAM172A protein has been implicated in cellular processes relevant to this condition.

Purpose:

  • To investigate the effect of the FAM172A protein on cell proliferation and apoptosis in HEK293 cells.
  • To explore the potential role of FAM172A in diabetic macroangiopathy.

Summary:

  • The FAM172A gene was successfully cloned and expressed in HEK293 cells.
  • Overexpression of FAM172A significantly increased cell proliferation (52% increase in optical density) and accelerated cell cycle progression into the S phase.
  • FAM172A overexpression markedly reduced apoptosis rates (by 38.5% for early and 29% for advanced apoptosis).

Impact:

  • FAM172A protein promotes cell proliferation and inhibits apoptosis, indicating its involvement in cell growth regulation.
  • These findings offer insights into the physiological functions of FAM172A and its potential contribution to diabetic macroangiopathy.

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