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Related Experiment Video

Updated: Jun 6, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Sorting out frontotemporal dementia?

Jada Lewis1, Todd E Golde

  • 1Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J-483, Gainesville, FL 32610-0244, USA. jada.lewis@mbi.ufl.edu

Neuron
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Mutations in the granulin gene cause frontotemporal lobar degeneration. Researchers identified Sortilin as a key neuronal receptor for progranulin, regulating its levels in the brain.

Related Experiment Videos

Last Updated: Jun 6, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Mutations in the granulin (GRN) gene, encoding progranulin (PGRN), are linked to frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U).
  • The specific neuronal receptor responsible for PGRN uptake in the central nervous system (CNS) remained unidentified.

Discussion:

  • This study identifies Sortilin (SORT1) as a crucial neuronal receptor for PGRN.
  • Sortilin mediates PGRN endocytosis, impacting PGRN levels within neurons.
  • This finding provides a molecular link between PGRN deficiency and FTLD-U pathogenesis.

Key Insights:

  • Sortilin (SORT1) is identified as a key neuronal receptor for progranulin (PGRN).
  • PGRN binds to Sortilin, which facilitates its endocytosis.
  • This interaction regulates PGRN levels in both in vitro and in vivo models.

Outlook:

  • Understanding the PGRN-Sortilin interaction may reveal new therapeutic targets for FTLD-U.
  • Further research can explore the role of Sortilin in other neurodegenerative conditions involving PGRN.
  • Investigating the downstream signaling pathways affected by PGRN endocytosis via Sortilin is warranted.