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Diffusion-weighted MRI with parallel imaging technique: apparent diffusion coefficient determination in normal
Luca Macarini1, Luca Pio Stoppino, Paola Milillo
1Department of Diagnostic Imaging, University of Foggia, Italy. l.macarini@unifg.it
Clinical Imaging
|November 25, 2010
Summary
Apparent diffusion coefficient (ADC) measurements using diffusion-weighted MRI can differentiate benign kidney abnormalities. These findings suggest ADC is a reliable tool for evaluating nonmalignant renal lesions.
Area of Science:
- Radiology
- Medical Imaging
- Renal Physiology
Background:
- Benign renal abnormalities require accurate diagnostic methods.
- Diffusion-weighted magnetic resonance imaging (DW MRI) offers insights into tissue microstructure.
Purpose of the Study:
- To evaluate the capability and reliability of apparent diffusion coefficient (ADC) measurements.
- To assess ADC in distinguishing various benign renal abnormalities.
Main Methods:
- Diffusion-weighted MRI with three b values (0, 300, 600 s/mm²) was performed on 25 healthy volunteers and 31 patients.
- Patients were categorized into seven groups based on renal pathology.
- Morphological kidney studies preceded DW MRI acquisition.
Main Results:
- Significant differences in ADC values were observed between healthy volunteers and patient groups, and among different pathological groups (e.g., cysts vs. renal failure, hydronephrosis vs. others).
- ADC values for cysts were higher than for renal failure and pyelonephritis.
- Hydronephrosis showed significantly different ADC values compared to cysts, renal failure, and pyelonephritis.
- A correlation was found between glomerular filtration rate and ADC.
Conclusions:
- ADC measurements show significant differences across various benign renal conditions.
- ADC appears to be a valuable tool for differentiating normal renal parenchyma from common nonmalignant renal lesions.
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