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Related Experiment Video

Updated: Jun 6, 2026

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

Specific cognitive training normalizes auditory sensory gating in schizophrenia: a randomized trial.

Tzvetan Popov1, Todor Jordanov, Brigitte Rockstroh

  • 1Department of Psychology, University of Konstanz, Konstanz, Germany.

Biological Psychiatry
|November 25, 2010
PubMed
Summary

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Cognitive training targeting auditory discrimination and verbal memory improved sensory gating and cognitive function in schizophrenia patients. This specific training normalized neural and cognitive performance.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Sensory gating, measured by the P50 response, is often impaired in schizophrenia, indicated by an abnormally large S2-evoked P50/S1-evoked P50 ratio.
  • This sensory gating deficit is linked to auditory/verbal system dysfunction, contributing to psychopathology and cognitive deficits in schizophrenia.
  • Computer-based cognitive training programs offer potential interventions for schizophrenia.

Purpose of the Study:

  • To compare the efficacy of two distinct 4-week computer-based cognitive training methods in schizophrenia patients.
  • To investigate the impact of auditory discrimination and verbal memory training versus broader cognitive training on sensory gating and cognitive performance.

Main Methods:

  • A randomized clinical trial involving 39 schizophrenia patients (ICD-F20.0).

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Last Updated: Jun 6, 2026

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Published on: December 26, 2013

Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique
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  • Participants were assigned to either Cognitive Exercises (CE) or Cognitive Package (Cogpack) training.
  • Magnetoencephalography (M50) and verbal learning/memory tests were used to assess training effects.

    • Main Results:

    • Schizophrenia patients exhibited higher pretreatment sensory gating ratios than healthy controls.
    • The CE group showed a significant decrease in gating ratios post-training, while the Cogpack group did not.
    • Cognitive test performance improved more in the CE group compared to the Cogpack group.

    Conclusions:

    • Specific psychological training, like the CE program, can alter neural performance in schizophrenia.
    • Targeted cognitive training effectively normalizes sensory gating and cognitive function in individuals with schizophrenia.