Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Cross-reactivity00:42

Cross-reactivity

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging Artificial Intelligence in Allergy, Asthma, and Immunology With Environmental Exposures.

Allergy·2026
Same author

Changes in the levels and predictors of per- and poly-fluoroalkyl substances in maternal plasma, relative to timelines of EPA PFOA Stewardship.

Environment international·2025
Same author

The Pregnancy, Arsenic, and Immune Response (PAIR) Study in rural northern Bangladesh.

Paediatric and perinatal epidemiology·2023
Same author

Editorial: Activation of Innate Immunity by Allergens and Allergenic Sources.

Frontiers in allergy·2022
Same author

A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort.

Environment international·2022
Same author

Department Chairs Weigh In: Environmental Health Education Is More Essential Than Ever.

American journal of public health·2021

Related Experiment Video

Updated: Jun 6, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Allergen-specific pattern recognition receptor pathways.

Marsha Wills-Karp1

  • 1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, United States. wildc7@cchmc.org

Current Opinion in Immunology
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Allergens trigger allergic diseases by activating innate immune responses through specific receptors. Understanding these molecular pathways can lead to new therapeutic targets for allergies.

More Related Videos

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Related Experiment Videos

Last Updated: Jun 6, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Area of Science:

  • Immunology
  • Molecular Biology
  • Allergy Research

Background:

  • Allergic diseases are a growing health concern in modern societies.
  • Identifying the molecular triggers of allergic responses is crucial.
  • Environmental proteins (allergens) are known to provoke allergic reactions in susceptible individuals.

Purpose of the Study:

  • To investigate the innate immune mechanisms underlying allergic responses.
  • To identify the molecular basis for how allergens induce allergic reactions.
  • To explore potential therapeutic targets for allergic diseases.

Main Methods:

  • Review of current scientific literature on allergen-innate immune interactions.
  • Analysis of data on pattern recognition receptors (PRRs) involved in allergy.
  • Examination of how allergens engage C-type lectin receptors and mimic toll-like receptor 4 signaling.

Main Results:

  • Allergenic proteins possess unique innate immune-activating capabilities.
  • Allergens engage C-type lectin receptors (dectin-2, DC-SIGN, mannose receptor) on dendritic cells.
  • Allergens can mimic toll-like receptor 4 signaling pathways in airway cells.

Conclusions:

  • Innate immune pathways activated by allergens are key drivers of allergic diseases.
  • Targeting specific innate immune receptors offers a promising strategy for allergy treatment.
  • Further elucidation of these pathways will define new therapeutic avenues for allergic conditions.