Effect of intravenous extracellular gadolinium based contrast medium on renal diffusion weighted images

The aim of this study was to compare precontrast and postcontrast renal diffusion-weighted images for signal intensity (SI), apparent diffusion coefficient (ADC), and lesion conspicuity.

In 62 patients (mean age, 54 ± 29; 29 men, 33 women) precontrast and postcontrast (0.1 mmol/kg of extracellular gadolinium-based contrast medium; mean, 3.3 ± 0.9 minutes], diffusion-weighted images at b values of 50 and 400 s/mm² were compared (3 T). The SI, signal-to-noise ratio, and ADC of the renal cortex, medulla, and lesions were measured. Lesion contrast-to-noise ratios (against the medulla and cortex) were calculated.

Postcontrast medullary SI decreased by 50% and cortical SI decreased by 33% and 39% on images at b = 50 s/mm² and b = 400 s/mm², respectively (P < .0001). The SI and signal-to-noise ratio of lesions did not change significantly after contrast, but lesion-medullary contrast-to-noise ratio was increased by 50% at both b = 50 s/mm² and b = 400 s/mm² (P < .005 and P = .0005, respectively) following contrast. Qualitative postcontrast lesion conspicuity was improved, with average scores of 2.8 ± 0.9 for all lesions (κ = 0.7 ± 0.08) and 3.2 ± 0.9 for solid lesions (κ = 0.82 ± 0.1). The ADC of renal cortex decreased (P = .03), but the ADC of renal medulla or renal lesions did not significantly change.

Postcontrast diffusion-weighted imaging causes a significant decrease in renal parenchymal signal without a significant change in lesion signal, resulting in increased lesion conspicuity.