Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study
View abstract on PubMed
Summary
This summary is machine-generated.Yearly mammography for women with a family history of breast cancer significantly lowers mortality risk. This screening approach helps detect cancers earlier, leading to better outcomes for high-risk individuals.
Area Of Science
- Oncology
- Radiology
- Preventive Medicine
Background
- Mammographic screening reduces breast cancer mortality in the general population.
- The impact of family history on screening effectiveness in younger women remains unclear.
Purpose Of The Study
- To determine if mammographic screening impacts disease stage and projected mortality in women under 50 with a significant family history of breast cancer.
Main Methods
- The FH01 study enrolled women at intermediate familial risk (under 50) for yearly mammography.
- Comparison groups included the UK Age Trial (general population) and a Dutch study (family history).
- Endpoints included tumor size, node status, grade, and 10-year mortality risk (Nottingham prognostic index).
Main Results
- Invasive tumors in the FH01 cohort were smaller, less node-positive, and of better grade compared to controls.
- Mean Nottingham prognostic index scores were significantly lower in the FH01 cohort.
- Adjusted 10-year mortality risk was significantly lower in the FH01 cohort (0.80 relative risk).
Conclusions
- Yearly mammography is effective for women with medium familial breast cancer risk.
- Screening leads to earlier detection and improved survival for high-risk women.