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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

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Potential antimalarials from Nigerian plants: a review.

J O Adebayo¹, A U Krettli

¹Laboratorio de Malaria, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte MG, Brazil. topebayo2002@yahoo.com

Journal of Ethnopharmacology

|November 25, 2010

Summary

This review explores Nigerian medicinal plants used for malaria treatment. Research shows some plants possess significant antimalarial activity, offering potential for new, affordable therapies against drug-resistant malaria.

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Area of Science:

Ethnobotany
Pharmacology
Tropical Medicine

Background:

Malaria remains a major infectious disease in tropical regions like Nigeria, with year-round transmission.
Local populations frequently utilize traditional plant-based remedies for malaria symptoms.
The rise of drug-resistant malaria necessitates novel therapeutic strategies.

Purpose of the Study:

To review medicinal plants used for malaria treatment in Nigeria.
To examine scientific evidence supporting the antimalarial efficacy of these plants and their compounds.
To highlight the potential of plant-derived compounds for developing new antimalarial drugs.

Main Methods:

Literature review of ethnobotanical data on Nigerian antimalarial plants.
Analysis of in vitro and in vivo studies on plant extracts and isolated compounds.
Investigation of potential mechanisms of action for active compounds.

Main Results:

Several Nigerian medicinal plants demonstrate significant antimalarial activity.
Active compounds have been isolated from some plants, with studied mechanisms of action.
Evidence supports the efficacy of certain plant-derived treatments against malaria parasites.

Conclusions:

Nigerian medicinal plants represent a valuable resource for antimalarial drug discovery.
Phytotherapies derived from these plants could offer affordable treatment options, particularly for vulnerable populations.
Further research into plant-based antimalarials is crucial to combat resistant malaria strains.