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Hyperglycemia and diabetes mellitus in children with pancreatitis

Vandana S Raman1, Robert W Loar, Venkat S Renukuntla

  • 1Department of Pediatrics, Section of Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA.

The Journal of Pediatrics
|November 25, 2010
PubMed

Insights

Children with pancreatitis face risks of hyperglycemia and diabetes mellitus (DM). Overweight children with severe pancreatitis, particularly those with seizure disorders, are more susceptible to developing DM after a single acute episode.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Gastroenterology

Background:

  • Pancreatitis in children can lead to metabolic complications.
  • Hyperglycemia and diabetes mellitus (DM) are potential sequelae of pancreatitis.
  • Understanding risk factors for DM in pediatric pancreatitis is crucial.

Purpose of the Study:

  • To identify risk factors associated with hyperglycemia and diabetes mellitus (DM) in pediatric patients diagnosed with pancreatitis.
  • To investigate the characteristics of children who develop DM following pancreatitis.

Main Methods:

  • Retrospective study of 176 pediatric patients (infants to 21 years) hospitalized with acute pancreatitis (AP), acute recurrent pancreatitis (ARP), or chronic pancreatitis.
  • Exclusion of patients with pre-existing DM or cystic fibrosis.
  • Analysis of clinical data to identify associations with hyperglycemia and post-pancreatitis DM.

Main Results:

  • Severe pancreatitis correlated with hyperglycemia; 41% of hyperglycemic patients required insulin.
  • Eight patients (4.5%) developed DM requiring insulin by discharge.
  • Post-pancreatitis DM was more common in overweight children, those with seizure disorders, and other comorbidities.

Conclusions:

  • Hyperglycemia and DM are significant risks in pediatric pancreatitis.
  • Comorbidities like seizure disorders and use of antiseizure medications may be linked to post-pancreatitis DM in children.
  • Unlike adults, children can develop DM from a single episode of acute pancreatitis.
Abstract

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