Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helicobacter pylori promotes dendritic cells maturation and inflammation via outer membrane vesicles.

Microbiological research·2026
Same author

Retraction Note: LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.

Journal of experimental & clinical cancer research : CR·2026
Same author

A Novel Autophagy Inhibitor <i>p</i>-Hydroxylcinnamaldehyde Suppresses Esophageal Squamous Cell Carcinoma by Targeting LDHA Phosphorylation-Mediated Metabolic Reprogramming.

Research (Washington, D.C.)·2026
Same author

H-chain ferritin-based magnetic nanoparticles targeting CD71 for magnetic resonance imaging diagnosis of esophageal squamous cell carcinoma and its precancerous lesions.

International journal of biological macromolecules·2025
Same author

Huo Po Xia Ling decoction exerts preventive and improvement effects on gastric precancerous lesions by remodeling gut microbiota and associated metabolites.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025
Same author

TRIM21-Mediated K11-Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Related Experiment Video

Updated: Jun 6, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Melanoma-associated antigen genes - an update.

Meixiang Sang1, Lifang Wang, Chunyan Ding

  • 1Tumor Research Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, PR China.

Cancer Letters
|November 25, 2010
PubMed
Summary

Melanoma-associated antigen (MAGE) genes are promising cancer immunotherapy targets due to their tumor-specific expression. This review explores MAGE classification, function, and their role in cancer immunotherapy.

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
08:18

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

Related Experiment Videos

Last Updated: Jun 6, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
08:18

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Dozens of melanoma-associated antigen (MAGE) genes have been identified, classified into MAGE-I and MAGE-II subfamilies based on expression and structure.
  • MAGE-I genes are highly expressed in various cancers but absent in normal adult tissues (except germ cells), making them attractive targets for cancer immunotherapy.
  • The precise functions of MAGE family members in cellular activities remain largely unknown.

Purpose of the Study:

  • To review the classification and expression patterns of MAGE family members in cancer.
  • To summarize the mechanisms of MAGE activation and their roles in cell cycle progression and apoptosis.
  • To discuss current knowledge regarding immunotherapy targeting the MAGE family.

Main Methods:

  • Literature review of MAGE family classification, expression, activation mechanisms, and functions.
  • Summary of existing research on cancer immunotherapy targeting MAGE antigens.

Main Results:

  • MAGE genes are categorized into MAGE-I and MAGE-II subfamilies.
  • MAGE-I genes exhibit tumor-specific expression, a key feature for immunotherapy.
  • MAGE family members influence cell cycle progression and apoptosis.

Conclusions:

  • MAGE genes represent significant targets for developing novel cancer immunotherapies.
  • Further research into MAGE functions can elucidate their roles in tumorigenesis and potential therapeutic applications.
  • Targeting MAGE antigens holds promise for improving cancer treatment strategies.