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Heme oxygenase-1 comes back to endoplasmic reticulum

Hong Pyo Kim1, Hyun-Ock Pae, Sung Hun Back

  • 1School of Biological Sciences, Ulsan University, Republic of Korea.

Biochemical and Biophysical Research Communications
|November 25, 2010
PubMed

Originally identified as a rate-limiting enzyme for heme catabolism, heme oxygenase-1 (HO-1) has expanded its roles in anti-inflammation, anti-apoptosis and anti-proliferation for the last decade. Regulation of protein activity by location is well appreciated. Even though multiple compartmentalization of HO-1 has been documented, the functional implication of this enzyme at these subcellular organelles is only partially elucidated. In this review we discuss the endoplasmic reticulum (ER)-residing HO-1 and its cytoprotective activity against ER stress.

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