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Related Concept Videos

Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

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Related Experiment Video

Updated: Jun 6, 2026

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

Environmental noise affects auditory temporal processing development and NMDA-2B receptor expression in auditory

Wei Sun1, Li Tang, Brian L Allman

  • 1Center for Hearing and Deafness, The State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA. weisun@buffalo.edu

Behavioural Brain Research
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Early life exposure to environmental noise impairs auditory temporal processing in rats, delaying development. This impairment is reversible and specific to early development, not adulthood.

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Related Experiment Videos

Last Updated: Jun 6, 2026

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Developmental Neuroscience

Background:

  • Auditory temporal processing is crucial for speech comprehension and sound discrimination.
  • Normal development enhances temporal processing acuity with age.
  • Early life noise exposure can impair auditory cortex development.

Purpose of the Study:

  • To investigate if early environmental noise exposure delays auditory cortex development and affects age-related improvements in temporal processing acuity.
  • To compare temporal processing in noise-reared rats versus controls.
  • To examine the impact of noise on N-methyl-D-aspartate (NMDA) receptor subunit expression in the auditory cortex.

Main Methods:

  • Used a gap detection threshold behavioral paradigm (gap-induced prepulse inhibition of the acoustic startle reflex).
  • Compared temporal processing acuity between rats reared in environmental noise and age-matched controls.
  • Assessed protein expression of NMDA-2A and NMDA-2B receptor subunits in the auditory cortex.

Main Results:

  • Rats reared in environmental noise exhibited poor adult temporal processing acuity (elevated gap detection threshold).
  • Noise-reared rats showed increased NR2B protein expression in the auditory cortex.
  • Moving noise-reared rats to quiet conditions improved their gap detection threshold, indicating delayed, not permanent, impairment.
  • Adult noise exposure did not affect mature gap detection thresholds.

Conclusions:

  • Early life environmental noise exposure impairs auditory temporal processing acuity by delaying auditory cortex development.
  • The observed impairment is reversible and specific to the critical developmental period.
  • Environmental noise during early life, but not adulthood, negatively impacts auditory temporal processing development.