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Antituberculosis potential of some ethnobotanically selected Malaysian plants
Suriyati Mohamad1, Nabihah Mohd Zin, Habibah A Wahab
1School of Biological Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia. suri@usm.my
Journal of Ethnopharmacology
|November 25, 2010
Summary
Malaysian plants show promise against tuberculosis. Researchers screened 78 extracts, finding 38 effective against Mycobacterium tuberculosis, validating traditional medicine uses.
Area of Science:
- Ethnomedicine
- Pharmacology
- Microbiology
Background:
- Malaysian traditional medicine utilizes local flora for respiratory ailments, including tuberculosis symptoms.
- Ethnobotanical knowledge guides the selection of medicinal plants for therapeutic potential.
Purpose of the Study:
- To screen 78 plant extracts from 70 Malaysian species for activity against Mycobacterium tuberculosis H37Rv.
- To validate the ethnomedicinal use of Malaysian plants in treating tuberculosis.
Main Methods:
- Plant extracts were prepared using 80% methanol maceration.
- Antituberculosis activity was assessed using the Tetrazolium bromide microplate assay (TEMA).
- Minimum inhibitory concentration (MIC) was determined for active extracts.
Main Results:
- 38 out of 78 plant extracts demonstrated antituberculosis activity.
- Activity was observed with minimum inhibitory concentrations (MICs) ranging from 400 to 1600 μg/ml.
- Angiopteris evecta leaf extract showed the highest activity (MIC = 400 μg/ml).
Conclusions:
- The study validates the ethnomedicinal use of certain Malaysian plants for tuberculosis symptom relief.
- Ethnobotanical screening is an effective strategy for identifying potential antituberculosis agents.
- Further research into these plant extracts could lead to novel tuberculosis treatments.
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