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Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
S Gorzalczany1, P López, C Acevedo
1Cátedra de Farmacología, Departamento de Farmacología, Facultad de Farmacia y Bioquímica, UBA, Junín 956 (C1113AAD), Buenos Aires, Argentina. sgorza@ffyb.uba.ar
Aim Of The Study:
In this study the anti-inflammatory activity of aqueous, dichloromethane (CH₂Cl₂) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Vell.) Engl. (Anacardiaceae) were evaluated.
Materials And Methods:
Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema.
Results:
MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4',7́dienyl) benzene obtained from CH₂Cl₂ extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3g/kg in an acute toxicity assay.
Conclusions:
The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.
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