Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chlorambucil lung toxicity.

F J Giles1, M P Smith, A H Goldstone

  • 1Department of Haematology, University College Hospital, London, UK.

Acta Haematologica
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase II study of elraglusib (9-ING-41), a GSK-3β inhibitor, in combination with gemcitabine plus nab-paclitaxel in previously untreated metastatic pancreatic cancer.

ESMO open·2025
Same author

Durable benefit of rituximab maintenance post-autograft in patients with relapsed follicular lymphoma: 12-year follow-up of the EBMT lymphoma working party Lym1 trial.

Bone marrow transplantation·2021
Same author

Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in <i>BRCA2</i>-Associated Prostate Cancer Resulting From Biallelic <i>BRCA2</i> Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations.

JCO precision oncology·2019
Same author

Malignancies and ustekinumab: an analysis of the U.S. Food and Drug Administration Adverse Event Reporting System and the European Union Drug Regulating Authorities Pharmacovigilance database.

The British journal of dermatology·2017
Same author

The evolving role of chemotherapy and hematopoietic cell transplants in Ph-positive acute lymphoblastic leukemia in adults.

Bone marrow transplantation·2017
Same author

Systematic analysis of early phase clinical studies for patients with breast cancer: Inclusion of patients with brain metastasis.

Cancer treatment reviews·2017
Same journal

Dapagliflozin in Patients with homozygous β-Thalassemia and Albuminuria.

Acta haematologica·2026
Same journal

Efficacy of second-generation FLT3 inhibitors in FLT3-mutated AML: A meta-analysis of randomized controlled trials.

Acta haematologica·2026
Same journal

Limited prognostic value of ELN classification and relevance of molecular ontogeny in acute myeloid leukemia post myeloproliferative neoplasms: a retrospective multicenter study.

Acta haematologica·2026
Same journal

Real-World Data on First Relapse in Multiple Myeloma: Treatment Patterns and Outcomes in Finland Using Automated Data Collection.

Acta haematologica·2026
Same journal

Comparative efficacy of donor lymphocyte infusions in augmenting graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation for patients with myeloid malignancies.

Acta haematologica·2026
Same journal

COVID-19 infection in patients with follicular lymphoma and related indolent B-cell lymphomas receiving anti-CD20 monoclonal antibody maintenance therapy.

Acta haematologica·2026
See all related articles

Oral chlorambucil and prednisone, used for chronic lymphocytic leukemia, can cause fatal lung fibrosis. This case highlights the severe pulmonary risks associated with these chemotherapy drugs.

Area of Science:

  • Oncology
  • Pulmonology
  • Pharmacology

Background:

  • Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
  • Chemotherapy regimens for CLL often include alkylating agents like chlorambucil and corticosteroids such as prednisone.
  • Long-term treatment strategies aim to manage disease progression and symptoms.

Observation:

  • A 67-year-old male patient with CLL received intermittent oral chlorambucil and prednisone for 3.5 years.
  • The patient subsequently developed progressive and ultimately fatal lung fibrosis.
  • This adverse event suggests a potential link between the prescribed therapy and pulmonary toxicity.

Findings:

  • The presented case report details a fatal instance of lung fibrosis.
  • The fibrosis is strongly suspected to be an iatrogenic effect of prolonged chlorambucil and prednisone treatment.

Related Experiment Videos

  • A review of existing literature on chlorambucil-induced lung disease is provided.

    • Implications:

    • This case underscores the critical need for vigilant monitoring of pulmonary function in patients undergoing long-term chlorambucil and prednisone therapy.
    • Awareness of potential chlorambucil-induced lung disease is crucial for oncologists and pulmonologists.
    • Further research into the mechanisms and risk factors for chemotherapy-induced lung injury is warranted.