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Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Related Experiment Video

Updated: Jun 6, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

RAS oncogene-mediated deregulation of the transcriptome: from molecular signature to function.

Reinhold Schäfer1, Christine Sers

  • 1Laboratory of Molecular Tumor Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany. reinhold.schaefer@charite.de

Advances in Enzyme Regulation
|November 25, 2010
PubMed
Summary

This study identifies key gene regulators in cancer, including Y-box binding protein 1 (YBX1) downstream of the MAPK pathway. It explores epigenetic regulation and HMGA2

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Related Experiment Videos

Last Updated: Jun 6, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Area of Science:

  • Cancer Biology
  • Molecular Oncology
  • Epigenetics

Background:

  • Transcriptome analysis is crucial for understanding cancer but functional insights into gene expression profiles remain limited.
  • The drivers of transcriptional alterations in cancer cells are not fully understood.
  • Current methods often provide correlative, not functional, gene expression data.

Purpose of the Study:

  • To identify functional regulators of gene expression downstream of the MAPK pathway in cancer cells.
  • To investigate the role of epigenetic mechanisms and specific transcription factors in cancer.
  • To explore therapeutic strategies targeting gene expression in cancer.

Main Methods:

  • Pathway-restricted gene expression profiling in RAS-transformed and RAS-expressing cancer cells.
  • Analysis of epigenetic regulation, including DNA methylation, in cell lines and colorectal cancer.
  • Assessment of high mobility AT-hook 2 (HMGA2) function in ovarian epithelial cells.
  • Integrated approach combining pathway interference, gene expression profiling, and computational analysis.

Main Results:

  • Identified Y-box binding protein 1 (YBX1) as a regulator of MAPK-dependent proliferation and gene expression.
  • Demonstrated the role of epigenetic regulation in controlling immune genes and its interaction with signaling pathways.
  • Characterized HMGA2 as a regulator of the RAS-responsive transcriptome in ovarian epithelial cells.

Conclusions:

  • YBX1 is a key regulator in MAPK-driven cancer processes, with potential as a prognostic factor.
  • Epigenetic modifications and signaling pathways interact to influence gene expression in cancer.
  • HMGA2 gene silencing presents a potential therapeutic avenue.