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Anaesthesia techniques for midazolam and flumazenil--an overview
1Institute for Anaesthesiology, University of Bonn, Federal Republic of Germany.
Acta Anaesthesiologica Scandinavica. Supplementum
|January 1, 1990
Summary
Midazolam, a benzodiazepine agonist, is effective for anesthesia induction with predictable plasma concentrations. Flumazenil can safely reverse prolonged recovery periods, ensuring prompt awakening when needed.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Midazolam is a benzodiazepine agonist used for anesthesia induction.
- Its use is associated with a predictable correlation between plasma concentration and anesthetic effect.
Purpose of the Study:
- To establish dosage recommendations for midazolam in total intravenous anesthesia.
- To investigate the antagonism of prolonged recovery periods with flumazenil.
Main Methods:
- Administering midazolam at doses of 0.15 to 0.2 mg/kg for anesthesia induction.
- Monitoring plasma concentrations and anesthetic effects.
- Using flumazenil titration (0.1 mg/min increments) to antagonize recovery.
Main Results:
- Midazolam exhibits low interindividual variability (20-25%) in plasma concentration-effect correlation.
- Hypnotic plasma concentrations of at least 250 ng/mL are recommended.
- Flumazenil effectively and safely antagonizes prolonged recovery, with a mean total dose of 0.4-0.5 mg for prompt awakening.
Conclusions:
- Midazolam dosage recommendations for total intravenous anesthesia are feasible.
- Flumazenil is a safe and effective antagonist for midazolam-induced prolonged recovery periods.
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