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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Cinacalcet improves bone density in post-kidney transplant hyperparathyroidism.
M E Cho1, Z Duan, C E Chamberlain
1Kidney Disease Branch, NIDDK, Clinical Center, NIH, Bethesda, Maryland 20892, USA. moniquec@intra.niddk.nih.gov
Transplantation Proceedings
|November 25, 2010
Summary
Cinacalcet offers a potential alternative for kidney transplant patients with hyperparathyroidism. This study found cinacalcet therapy improved bone mineral density (BMD) and was well-tolerated.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- Persistent hyperparathyroidism is a complication in kidney transplant recipients.
- Cinacalcet is an emerging treatment option for hyperparathyroidism.
- The impact of cinacalcet on bone mass density (BMD) post-transplant is not well-established.
Purpose of the Study:
- To evaluate the effect of cinacalcet on BMD in kidney transplant recipients with persistent hyperparathyroidism.
- To compare BMD changes in patients treated with cinacalcet versus a matched control group.
Main Methods:
- Retrospective analysis of 163 kidney transplant recipients from 1999-2007.
- Comparison of 8 patients on cinacalcet with 15 matched controls.
- Assessment of BMD changes at 12, 24, and 36 months post-transplant using a repeated-measures mixed model.
Main Results:
- Cinacalcet therapy significantly reduced serum calcium levels.
- Patients receiving cinacalcet showed a greater increase in hip BMD over 36 months.
- Cinacalcet was well-tolerated with no significant adverse events reported.
Conclusions:
- Cinacalcet therapy may offer a beneficial effect on bone density in kidney transplant recipients.
- Further research is warranted to confirm these findings and optimize treatment protocols.
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