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Related Concept Videos

Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
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Updated: Jun 6, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

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Published on: July 14, 2023

Cinacalcet improves bone density in post-kidney transplant hyperparathyroidism.

M E Cho1, Z Duan, C E Chamberlain

  • 1Kidney Disease Branch, NIDDK, Clinical Center, NIH, Bethesda, Maryland 20892, USA. moniquec@intra.niddk.nih.gov

Transplantation Proceedings
|November 25, 2010
PubMed
Summary

Cinacalcet offers a potential alternative for kidney transplant patients with hyperparathyroidism. This study found cinacalcet therapy improved bone mineral density (BMD) and was well-tolerated.

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Persistent hyperparathyroidism is a complication in kidney transplant recipients.
  • Cinacalcet is an emerging treatment option for hyperparathyroidism.
  • The impact of cinacalcet on bone mass density (BMD) post-transplant is not well-established.

Purpose of the Study:

  • To evaluate the effect of cinacalcet on BMD in kidney transplant recipients with persistent hyperparathyroidism.
  • To compare BMD changes in patients treated with cinacalcet versus a matched control group.

Main Methods:

  • Retrospective analysis of 163 kidney transplant recipients from 1999-2007.
  • Comparison of 8 patients on cinacalcet with 15 matched controls.
  • Assessment of BMD changes at 12, 24, and 36 months post-transplant using a repeated-measures mixed model.

Main Results:

  • Cinacalcet therapy significantly reduced serum calcium levels.
  • Patients receiving cinacalcet showed a greater increase in hip BMD over 36 months.
  • Cinacalcet was well-tolerated with no significant adverse events reported.

Conclusions:

  • Cinacalcet therapy may offer a beneficial effect on bone density in kidney transplant recipients.
  • Further research is warranted to confirm these findings and optimize treatment protocols.