Related Experiment Video
Updated: Jun 6, 2026
16:15
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Delayed kidney allograft function after simultaneous pancreas-kidney transplantation
E B Rangel1, C S Melaragno, A M Gonzalez
1Division of Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil. erikabr@uol.com.br
Transplantation Proceedings
|November 25, 2010
Summary
Simultaneous pancreas-kidney transplantation (SPKT) survival depends on avoiding delayed graft function, acute rejection, and infections. Improving deceased donor care can reduce complications and enhance patient outcomes.
Area of Science:
- Nephrology
- Transplantation Immunology
- Surgical Oncology
Background:
- Simultaneous pancreas-kidney transplantation (SPKT) is a vital treatment for end-stage renal disease in insulin-dependent patients.
- This study evaluates outcomes and risk factors in SPKT recipients.
Purpose of the Study:
- To identify key determinants of patient and kidney allograft survival after SPKT.
- To explore factors contributing to complications such as delayed graft function (DGF).
Main Methods:
- Analysis of one-year survival rates in 150 SPKT patients using Cox regression and Kaplan-Meier methods.
- Identification of uni- and multivariate risk factors for allograft and patient survival.
Main Results:
- One-year patient and kidney allograft survival rates were 82% and 80%, respectively.
- Delayed graft function (DGF), acute kidney rejection, and intra-abdominal infection (IAI) significantly impacted survival.
- DGF was associated with longer dialysis duration, prolonged cold ischemia time, older donor age, and higher donor serum sodium.
Conclusions:
- DGF, acute rejection, and IAI are primary factors affecting SPKT outcomes.
- Enhanced care for deceased donors may mitigate DGF and improve post-transplant survival.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...