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Updated: Jun 6, 2026
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Aerosolized tacrolimus: a case report in a lung transplant recipient
D Hayes1, J B Zwischenberger, H M Mansour
1Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. don.hayes@uky.edu
Transplantation Proceedings
|November 25, 2010
Summary
Bronchiolitis obliterans syndrome (BOS) significantly impacts lung transplant survival. This study explores aerosolized tacrolimus as a novel treatment, showing promising clinical improvements in a single patient with BOS.
Area of Science:
- Pulmonary Medicine
- Transplantation Immunology
Background:
- Bronchiolitis obliterans syndrome (BOS) is a primary cause of long-term lung transplant failure.
- Limited therapeutic options exist for managing BOS, necessitating novel treatment strategies.
Observation:
- A case study investigated aerosolized tacrolimus administration in a lung transplant recipient diagnosed with BOS.
- The patient received tacrolimus via nebulization as a therapeutic intervention.
Findings:
- The lung transplant recipient experienced notable clinical improvement in functional capacity.
- Enhanced oxygenation was observed in the patient following the administration of aerosolized tacrolimus.
Implications:
- Aerosolized tacrolimus presents a potential new therapeutic avenue for managing BOS post-lung transplantation.
- Further clinical trials are warranted to validate the efficacy and safety of nebulized tacrolimus in a broader patient cohort.
