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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

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Published on: September 26, 2013

The role of Th17 cytokines in primary mucosal immunity

Jay K Kolls1, Shabaana A Khader

  • 1LSU Health Sciences Center, Department of Genetics, CSRB 657, 533 Bolivar St., New Orleans, LA 70112, USA. jkolls@lsuhsc.edu

Cytokine & Growth Factor Reviews
|November 25, 2010
PubMed

The T helper type 17 (Th17) lineage of CD4+ T-cells produce several effector molecules including IL-17A, IL-17F, IL-21, and IL-22. In addition to CD4+, αβ T-cells, these cytokines can be produced by natural killer and γδ T-cells. These effector cytokines can be produced rapidly upon infection at mucosal sites and evidence to date strongly implicates that this arm of the immune system plays a critical role in mucosal immunity to many extracellular pathogens. Moreover these cytokines can also coordinate adaptive immunity to some intracellular pathogens. In this review, we will highlight recent progress in our understanding of these cytokines, and mechanisms of their effector function in the mucosa.

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