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Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

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Expanding the Donor Pool With Normothermic Ex Vivo Liver Perfusion: The Future Is Now.

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Regulating T Cell Behavior.

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Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
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One Size Does Not Fit All--Regional Variation in the Impact of the Share 35 Liver Allocation Policy.

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Surgical technique in transplantation: how much does it matter?

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Acute Rejection Mediated by Preformed Anti-HLA-C Antibody in a Kidney Transplant Patient: A Case Report.

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Related Experiment Video

Updated: Jun 6, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Immunoregulation and tolerance.

S J Knechtle1

  • 1Knechtle, Division of Transplantation, Emory University School of Medicine, Atlanta, GA 30322, USA. Stuart.Knechtle@emoryhealthcare.org

Transplantation Proceedings
|November 25, 2010
PubMed
Summary
This summary is machine-generated.

Sirolimus enhances regulatory T-cells (Tregs) to promote organ transplant tolerance. However, its effects on T-memory and B-cells require combination therapy and new markers to measure tolerance effectively.

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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

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Last Updated: Jun 6, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

  • Immunology
  • Transplantation Biology

Background:

  • Regulatory T-cells (Tregs) are crucial for suppressing immune responses against transplanted organs.
  • Promoting Treg development and function is a key strategy for achieving transplant tolerance.

Purpose of the Study:

  • To evaluate sirolimus as a component of strategies aimed at promoting transplant tolerance.
  • To address potential limitations of sirolimus, such as its impact on T-memory and B-cells.

Main Methods:

  • Investigating the in vivo effects of sirolimus on Treg development and function.
  • Considering the necessity of combination immunosuppressive therapies to manage B-cell responses.
  • Highlighting the need for novel genotypic markers to assess tolerance induction.

Main Results:

  • Sirolimus demonstrates the ability to enhance Treg development and function in vivo.
  • Sirolimus's Treg-promoting effects may be counteracted by its influence on T-memory cells and B-cell activation.
  • Combination therapy with other immunosuppressants is likely necessary to control B-cell responses.

Conclusions:

  • Sirolimus holds promise for promoting transplant tolerance by enhancing Tregs.
  • Careful consideration of sirolimus's broader immunomodulatory effects is essential.
  • Development of specific biomarkers is crucial for monitoring tolerance in liver and kidney transplant recipients.