Management of combined vascular malformations
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Updated: Jun 6, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Ann M Kulungowski1, Steven J Fishman
1Department of Surgery, Vascular Anomalies Center, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Insights
This study categorizes combined vascular malformations as slow-flow or fast-flow lesions, often linked to tissue and skeletal overgrowth. It details the diagnosis, management, and treatment for specific complex vascular anomalies.
Area of Science:
- Vascular Medicine
- Medical Genetics
- Pediatric Surgery
Background:
- Combined vascular malformations are classified as slow-flow or fast-flow lesions.
- Many combined lesions present with associated soft tissue and skeletal hypertrophy.
- Understanding these complex lesions is crucial for effective patient care.
Purpose of the Study:
- To discuss the diagnosis of complex vascular malformations.
- To outline the management strategies for these conditions.
- To review treatment options for patients with specific combined vascular anomalies.
Main Methods:
- Literature review on combined vascular malformations.
- Case study analysis of patients with capillary lymphaticovenous malformation, capillary-arteriovenous malformation, and capillary-arteriovenous fistulas.
- Discussion of diagnostic criteria and therapeutic approaches.
Main Results:
- Combined lesions exhibit diverse clinical presentations.
- Association with soft tissue and skeletal hypertrophy is common.
- Specific syndromes like CLOVES syndrome require tailored management.
Conclusions:
- Accurate diagnosis is essential for appropriate management of combined vascular malformations.
- Multidisciplinary approaches are often necessary for optimal treatment outcomes.
- Further research into the underlying mechanisms and novel therapies is warranted.
Abstract:
Like single-channel-type vascular malformations, combined lesions are categorized as slow-flow and fast-flow lesions. Many of the combined vascular malformations are associated with soft tissue and skeletal hypertrophy. This article discusses the diagnosis, management, and treatment of patients with capillary lymphaticovenous malformation, capillary-arteriovenous malformation, and capillary-arteriovenous fistulas and congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal anomalies syndrome.
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