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Glucagonlike peptide-1 receptor: an example of translational research in insulinomas: a review
Emanuel Christ1, Damian Wild, Jean Claude Reubi
1Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital of Berne Inselspital, Freiburgstrasse 15, CH 3010 Berne, Switzerland.
Abstract:
Glucagonlike peptide-1 receptors (GLP-1R) play an increasingly important role in endocrine gastrointestinal tumor management. In particular, virtually all benign insulinomas express GLP-1R in high density. Exendin-4 is a GLP-1 analog that has a longer half-life than GLP-1. Targeting GLP-1R by (111)In-DOTA-exendin-4 or (111)In-DPTA-exendin-4 offers a new approach that permits the successful localization of small benign insulinomas. It is likely that this new noninvasive technique has the potential to replace the invasive localization by selective arterial stimulation and venous sampling.
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