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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Assembling ligands in situ using bioorthogonal boronate ester synthesis
Sung Bin Y Shin1, Ramiro D Almeida, Guillermo Gerona-Navarro
1Department of Pharmacology, Weill Medical College, Cornell University, New York, NY 10065, USA.
Abstract:
Many molecules that could manipulate cellular function are not practical due to their large size and concomitant undesirable pharmocokinetic properties. Here, we describe a bioorthogonal, highly stable boronate ester (HiSBE) synthesis and use this reaction to synthesize a biologically active molecule from smaller precursors in a physiological context. The rapid rate of HiSBE synthesis suggests that it may be useful for assembling a wide variety of biologically active molecules in physiological solutions.
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