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Updated: Jun 6, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
A Biomechanical model of spiculated tumours under mammographic compressions
Carolina Wessel1, Julia A Schnabel, Michael Brady
1Department of Engineering Science, University of Oxford, Parks Road, OX1 3PJ, UK. cwessel@robots.ox.ac.uk
Abstract:
The aim of this paper is to introduce effects well known to clinicians -but neglected to date- in the biomechanical modelling of breast malignant tumours. We develop a model of an isolated stellate breast tumour under mammographic compression forces. We study a range of reported mechanical properties, both linear elastic and hyperelastic. We also introduce different volumes of increased density/stiffness around the tumour. We show that each of these issues has a non-negligible effect on stresses and strains/deformations.
