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Updated: Jun 6, 2026

High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence
Published on: October 28, 2025
Denoising of LSFCM images with compensation for the photoblinking/photobleaching effects
1Institute for Systems and Robotics and with Instituto Superior de Engenharia de Lisboa, Portugal. irodrigues@deetc.isel.ipl.pt
Abstract:
Fluorescence confocal microscopy images present a low signal to noise ratio and a time intensity decay due to the so called photoblinking and photobleaching effects. These effects, together with the Poisson multiplicative noise that corrupts the images, make long time biological observation processes very difficult.
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