Evaluation framework for the multilevel macroscopic models of solid tumor growth in the glioma case

This paper investigates the applicability of multilevel macroscopic models for simulating solid tumor growth in the invasive glioblastoma multiforme (GBM) case. The continuum case approach tumor model based on the diffusion reaction equation is evaluated on a pre-segmented tomographic atlas where all tissue properties are known a priori. The atlas is further registered on a real clinical case where the tumor invasion status is gauged in two successive points in time. Based on the latter, the model attempts to fully replicate tumor growth taking into account tissue based properties as identified from the atlas template. The whole process is performed on a clinical platform specially designed to facilitate precise identification and delineation of tumors of large number of 3D tomographic datasets by an expert clinician. The promising results presented encourage the potential clinical applicability of the proposed model in the glioma case and identify crucial points and direction of further model refinement and research.