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Updated: Jun 6, 2026

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes
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Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

An implantable integrated low-power amplifier-microelectrode array for Brain-Machine Interfaces.

Erin Patrick1, Viswanath Sankar, William Rowe

  • 1Department of Electrical and Computer Engineering, University of Florida, Gainesville, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
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Researchers developed a fully implantable neural recording system for Brain-Machine Interfaces (BMI). This system reliably processed cortical neuron activity for 42 days in rodents, demonstrating its potential for advanced BMI applications.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Designing implantable Brain-Machine Interfaces (BMI) requires systems capable of reliably processing large ensembles of cortical neuron activity.
  • Existing systems face challenges in long-term stability and signal fidelity for chronic neural recordings.

Purpose of the Study:

  • To design, fabricate, and test a novel polyimide-based microelectrode array integrated with a low-power amplifier for fully implantable neural recording.
  • To evaluate the performance and reliability of the developed system for Brain-Machine Interface applications over an extended period.

Main Methods:

  • Fabrication of a polyimide microelectrode array using planar micromachining MEMS processes.
  • Hybrid packaging of the electrode array with a low-power amplifier die using flip-chip bonding.

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Last Updated: Jun 6, 2026

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes
13:49

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

  • In-vivo testing including acute and chronic neural recordings from a rodent for 42 days.

    • Main Results:

    • Successful fabrication and integration of the microelectrode array with a low-power amplifier.
    • Obtained stable acute and chronic neural recordings over a 42-day period in a rodent model.
    • Characterized system performance with a noise floor of 4.5 microVrms and an average signal-to-noise ratio of 3.8.

    Conclusions:

    • The developed fully implantable neural recording system demonstrates feasibility for long-term Brain-Machine Interface applications.
    • The polyimide-based microelectrode array and integrated amplifier provide reliable processing of cortical neuron activity.
    • The FWIRE system shows promise for advancing the capabilities of neural recording technologies.