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Updated: Jun 6, 2026

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
Published on: April 19, 2024
Online estimation of respiratory mechanics in non-invasive pressure support ventilation: a bench model study
Qestra Mulqueeny1, Didier Tassaux, Laurence Vignaux
1ResMed Pty Ltd, and the Graduate School of Biomedical Engineering, University of New South Wales, Sydney 2052, Australia.
Abstract:
An online algorithm for determining respiratory mechanics in patients using non-invasive ventilation (NIV) in pressure support mode was developed and embedded in a ventilator system. Based on multiple linear regression (MLR) of respiratory data, the algorithm was tested on a patient bench model under conditions with and without leak and simulating a variety of mechanics. Bland-Altman analysis indicates reliable measures of compliance across the clinical range of interest (± 11-18% limits of agreement). Resistance measures showed large quantitative errors (30-50%), however, it was still possible to qualitatively distinguish between normal and obstructive resistances. This outcome provides clinically significant information for ventilator titration and patient management.
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