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Updated: Jun 6, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

CMOS/microfluidic Lab-on-chip for cells-based diagnostic tools.

M Sawan1, M A Miled, E Ghafar-Zadeh

  • 1Polystim Neurotechnologies Laboratory, Dept. of Elec. Eng., Polytechnique Montréal, Canada.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
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This paper introduces novel Lab-on-chip devices for efficient cell sensing and manipulation, utilizing advanced microfluidic and circuit techniques for precise cell detection and handling.

Area of Science:

  • Biotechnology
  • Electrical Engineering
  • Microfluidics

Background:

  • Lab-on-chip (LOC) devices are crucial for cell analysis.
  • Efficient cell manipulation and detection require integrated sensing and microfluidic systems.

Purpose of the Study:

  • To present novel cell sensing and manipulation methods using Lab-on-chip platforms.
  • To introduce new circuit, microfluidic, and packaging techniques for enhanced cell handling.

Main Methods:

  • Development of high-sensitivity capacitive sensors (200 mV/fF) integrated with CMOS technology.
  • Implementation of direct-write microfluidic fabrication.
  • Utilizing low-pressure liquid injection (< 0.65 psi) and low-voltage manipulation signals.
  • Employing various electrode array designs (square, L-shaped) for cell manipulation.

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Related Experiment Videos

Last Updated: Jun 6, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

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Published on: April 17, 2021

Main Results:

  • Demonstrated efficient cell manipulation and detection capabilities.
  • Achieved high sensitivity in sensing circuits.
  • Successfully fabricated microfluidic channels directly on CMOS sensors.
  • Validated the use of different electrode arrays for diverse cell types.

Conclusions:

  • The proposed Lab-on-chip platform offers efficient and sensitive cell sensing and manipulation.
  • The integrated approach using novel microfluidic and circuit designs advances cell-based assays.
  • This technology has potential applications in various cell analysis and sorting tasks.