Related Experiment Video
Updated: Jun 6, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Changes of hippocampal CA3-CA1 population nonlinear dynamics across different training sessions in rats performing a
Rosa H M Chan1, Dong Song, Anushka V Goonawardena
1Center for Neural Engineering, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. homchan@usc.edu
Abstract:
Delayed-nonmatch-to-sample (DNMS) task is memory-dependent. Hippocampal CA3 and CA1 cells were shown to be encoding the required spatial and temporal information to complete this task. In order to identify possible changes in neural population nonlinear dynamics during learning of the DNMS task, we have first modeled the input-output transformation of spike trains across brain subregions from learning animals using a multiple-input, multiple-output (MIMO) nonlinear dynamic model. The feedforward and feedback kernels describing the relations between hippocampal CA3 and CA1 subregions have shown significant changes at different training sessions.

