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Related Experiment Video

Updated: Jun 6, 2026

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
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Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

A high-voltage, high-current CMOS pulse generator ASIC for deep brain stimulation.

Noppasit Laotaveerungrueng1, Rosa R Lahiji, Steven L Garverick

  • 1Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA. noppasit@case.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
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A novel integrated circuit generates high-voltage, high-current pulses for applications like deep brain stimulation (DBS). This arbitrary function generator chip offers precise control over stimulation parameters for targeted therapeutic interventions.

Area of Science:

  • Integrated circuit design
  • Biomedical engineering
  • Neurotechnology

Background:

  • Deep brain stimulation (DBS) requires precise electrical stimulation.
  • Existing solutions for DBS pulse generation can be complex and bulky.
  • Need for miniaturized, on-chip arbitrary waveform generation for advanced neuromodulation.

Purpose of the Study:

  • To present a high-voltage, high-current pulse generator Application-Specific Integrated Circuit (ASIC).
  • To demonstrate an on-chip arbitrary function generator for versatile waveform synthesis.
  • To evaluate the chip's suitability for deep brain stimulation electrode applications.

Main Methods:

  • Development of an ASIC using 0.35-μm high-voltage CMOS technology.
  • Implementation of eight independently-controlled biphasic output channels.

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  • Programmable control over pulse parameters including current/voltage, frequency, pulse width, and phase.

    • Main Results:

    • The ASIC delivers up to 5.04 mA current or 9.45 V voltage with 6-bit resolution.
    • Stimulation frequency adjustable from 3 Hz to 5 kHz; pulse width from 20 μs to 640 μs.
    • Independent channel programming enables arbitrary waveform generation for targeted stimulation.

    Conclusions:

    • The developed ASIC provides a monolithic, on-chip arbitrary function generator solution.
    • Its configuration makes it ideal for deep brain stimulation electrode applications.
    • Enables precise, targeted stimulation through current steering for therapeutic benefits.