A neural repair treatment with gait training improves motor function recovery after spinal cord injury

Aimed to develop an effective approach for treating spinal cord injury (SCI), we investigated the effectiveness of a treatment strategy that combined peripheral nerve grafting, nerve growth factors and functional task based physical therapy on non-human primate models. SCI was by unilateral surgical hemi-section at the T8 spine level (approximately 4 mm gap). Two of the 4 subjects as treatment received the transplants of sural nerve segments as well as infused acidic fibroblast growth factor (aFGF) to the injured spinal cord. All four subjects received physical therapy and bipedal walking training on a treadmill to promote motor function recovery. A comprehensive evaluation system including general observation in the home cage, behavioral test and clinic score system was used to assess the effect of the treatment. The recovery of functional mobility in treated group is much faster than the control group. The treated group started to move around in their cages within a week and continued to improve in walking performance as measured by gait symmetry, while the control group developed spasticity and rigidity with a much slower and less functional recovery of mobility. All these results suggest that the treatment strategy of peripheral nerve grafting with aFGF combined with physical therapy is effective to treat SCI.