Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling the Effects of Short-Range Randomness in Packed Sphere Beds.

Analytical chemistry·2026
Same author

Corrigendum to "A new chromatographic response function with automatically adapting weight factor for automated method development" [Journal of Chromatography A, 1727 (2024), 465008].

Journal of chromatography. A·2025
Same author

A survey among Flemish gastroenterologists about endoscopic sedation practices in colorectal cancer screening.

Acta gastro-enterologica Belgica·2024
Same author

Simulation of ambulatory electrodermal activity and the handling of low-quality segments.

Computer methods and programs in biomedicine·2023
Same author

Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rats.

European review for medical and pharmacological sciences·2023
Same author

Learning based Quality Indicator Aiding Heart Rate Estimation in Wrist-Worn PPG.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2021

Related Experiment Video

Updated: Jun 6, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Integrated fluidic system for bio-molecule separation.

M Hiraoka1, P Fiorini, L Zhang

  • 1Imec, Kapeldreef 75, 3001 Leuven, Belgium. hiraoka.maki@jp.panasonic.com

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
Summary

A novel integrated fluidic system effectively separates biomolecules using a conductive polymer actuator and silicon micro-pillar filter. This system achieves over 10% strain, enabling precise microfluidic control for molecular separation.

More Related Videos

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device
06:28

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device

Published on: February 2, 2024

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
10:32

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids

Published on: March 2, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device
06:28

Single Step Isolation of Extracellular Vesicles from Large-Volume Samples with a Bifurcated A4F Microfluidic Device

Published on: February 2, 2024

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
10:32

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids

Published on: March 2, 2012

Area of Science:

  • Biotechnology
  • Microfluidics
  • Materials Science

Background:

  • Biomolecule separation is crucial for diagnostics and research.
  • Existing methods often face limitations in efficiency and precision.
  • Integrated fluidic systems offer potential for streamlined molecular analysis.

Purpose of the Study:

  • To develop and characterize an integrated fluidic system for biomolecule separation.
  • To evaluate the performance of a novel conductive polymer actuator and silicon micro-pillar filter.
  • To demonstrate the system's capability in separating DNA fragments of varying lengths.

Main Methods:

  • Fabrication of an integrated fluidic system comprising a conductive polymer actuator and a silicon micro-pillar filter.
  • Characterization of actuator performance, including strain (over 10%) and resulting fluid flow (3 microL/min).
  • Separation of a mixture of DNA fragments (300 and 400 base-pair) using the system and chromatographic techniques.

Main Results:

  • The integrated fluidic system successfully separated DNA fragments based on length.
  • The conductive polymer actuator demonstrated significant strain (>10%), driving microfluidic flow.
  • The silicon micro-pillar filter effectively facilitated the chromatographic separation process.

Conclusions:

  • The developed integrated fluidic system provides an effective platform for biomolecule separation.
  • The combination of a high-strain polymer actuator and micro-pillar filter enables precise microfluidic control.
  • This technology holds promise for advancing molecular separation techniques in various scientific fields.