Related Experiment Video
Updated: Jun 6, 2026
Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
Published on: June 21, 2022
Differential stimulation of ON and OFF retinal ganglion cells: a modeling study
Tatiana Kameneva1, Hamish Meffin, Anthony N Burkitt
1Department of Electrical Engineering, The University of Melbourn, Australia. tkam@unime.edu.au
Abstract:
A model of the electrophysiological properties of ON and OFF retinal ganglion cells (RGCs) was constrained and validated using experimental data from the literature. Our simulations support experimental findings that differences in the magnitude of the T-type Ca(2+) current explain differences in the intrinsic electrophysiology of ON and OFF RGCs. The models are used to investigate the potential for differential stimulation of ON and OFF RGCs during neuroprosthetic stimulation with sinusoidal current. The model predicts that OFF cells fire preferential over ON cells in a frequency band around 10 Hz.
