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Related Experiment Video

Updated: Jun 6, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

Implantable micropump technologies for murine intracochlear infusions.

D G Johnson1, M J Waldron, R D Frisina

  • 1Rochester Institute of Technology, Rochester, NY 14623, USA. dgj2607@rit.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
Summary

Developing controlled infusion systems for the tiny mouse inner ear is difficult. New technologies enable a miniaturized implantable pump for precise, low-volume drug delivery in mice.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Drug Delivery Systems

Background:

  • Mouse inner ear volumes (600 nL) present significant challenges for controlled infusion system development.
  • Existing technologies lack the miniaturization and power efficiency required for implantable murine drug delivery.

Purpose of the Study:

  • To develop key technologies for a miniaturized, low-power implantable pump for murine intracochlear infusions.
  • To enable effective and controlled drug delivery in space-constrained applications like mouse models.

Main Methods:

  • Developed low-volume, biocompatible capillary-to-microfluidic channel interconnects (withstanding up to 827 kPa).
  • Integrated surface-micromachined resistive bridges for anemometry-based, low-power flow rate measurement in microfluidic channels.

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Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
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Related Experiment Videos

Last Updated: Jun 6, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
12:17

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

  • Engineered deformable diaphragms and simultaneous microfluidic channel coating for a biocompatible fluid path.

    • Main Results:

    • Achieved interconnects with <20 nL volume loss, suitable for in-plane pump integration.
    • Optimized flow sensors for ultra-low flow rates and low power consumption.
    • Successfully created a fully integrated, biocompatible fluid path within the microfluidic pump system.

    Conclusions:

    • The developed technologies enable a novel drug delivery system for space-constrained applications, specifically subcutaneous implantation in mice.
    • This advancement facilitates precise, controlled intracochlear infusions in mouse models.
    • The system is suitable for research requiring ultra-low volume, high-pressure fluid delivery.