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A linearized current stimulator for deep brain stimulation.

Ding-Lan Shen1, Yu-Jung Chu

  • 1Department of Electrical Engineering, Fu Jen Catholic University, Taipei 24205, Taiwan. dlshen@ee.fju.edu.tw

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 25, 2010
PubMed
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This study presents a new front-end stimulator for deep brain stimulation (DBS) therapy in Parkinson's disease. The design uses a low-power switched-capacitor digital-to-analog converter (DAC) and advanced techniques for precise current control.

Area of Science:

  • Biomedical Engineering
  • Electrical Engineering
  • Neuroscience

Background:

  • Parkinson's disease therapy often involves deep brain stimulation (DBS).
  • Effective DBS requires precise control over stimulation parameters like current and pulse width.
  • Existing stimulator designs face challenges in power consumption, circuit area, and linearity.

Purpose of the Study:

  • To develop a low-power, high-linearity front-end stimulator for implantable DBS systems.
  • To improve the precision and efficiency of current delivery for Parkinson's disease treatment.
  • To reduce the overall circuit area through component sharing.

Main Methods:

  • Utilized a low-power switched-capacitor digital-to-analog converter (DAC).
  • Integrated voltage-to-current transconductance amplifiers for adjustable output currents.

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  • Implemented a distortion cancellation technique to enhance linearity.
  • Employed bridge switching and programmable pulse generation for biphasic waveforms.

    • Main Results:

    • Achieved adjustable output currents from 0 to 165 microA into a 10 kΩ load.
    • Provided programmable pulse widths ranging from 8 to 120 microseconds.
    • Enabled stimulation frequencies between 126 and 244 Hz.
    • Demonstrated improved linearity through the distortion cancellation technique.

    Conclusions:

    • The developed front-end stimulator is suitable for implantable DBS applications in Parkinson's disease.
    • The design offers a balance of low power consumption, high linearity, and reduced circuit area.
    • This technology advances the potential for more effective and efficient neuromodulation therapies.