Converging micro-nano-bio technologies towards integrated in-vitro testing systems: Current activities and future...

Area of Science:

• Convergence of Information & Communication Technologies (ICT), Micro-Nano Technologies, and Bio-Technologies.
• Development of miniaturized, smart, and integrated systems for healthcare applications.
• Focus on Micro-Nano-Bio Systems (MNBS) for in-vitro diagnostics and human-interactive technologies.

Background:

• Emerging MNBS are poised to impact healthcare, the ageing population, and overall well-being.
• European Union's R&D programs prioritize ICT for MNBS development.
• MNBS applications include in-vitro testing (lab-on-chips) and human-interactive systems (implants, surgical robotics).

Purpose of the Study:

• To present background information on MNBS in-vitro testing for a mini-symposium.
• To discuss current challenges, solutions, and open issues in MNBS technology.
• To highlight the integration of technology building blocks into smart, miniaturized systems.

Main Methods:

• Research and development of technology building blocks for in-vitro testing.
• Focus on sample preparation, ultra-sensitive detection, molecular recognition chemistry, and microfluidics.
• Integration of these components into advanced systems like biochips and Lab on Chip devices.

Main Results:

• Development of miniaturized systems for in-vitro testing, including DNA & protein arrays, biochips, Lab on Chip, and Lab on Card.
• Advancements in technology building blocks such as sample preparation and detection techniques.
• Progress in integrating microfluidics and molecular recognition for enhanced diagnostic capabilities.

Conclusions:

• MNBS in-vitro testing holds significant promise for healthcare advancements.
• Continued research is needed to overcome challenges and meet technological and socioeconomic demands.
• The presented work provides foundational insights for the mini-symposium on MNBS in-vitro testing.