Destructive power dynamics of alpha-theta oscillations via spike and wave in CA3

The power dynamics of alpha-theta oscillations via inter-ictal spikes and waves (SWs) in CA3 is investigated by means of Hilbert transform and the statistical method based on CA3 channel of LFP(Local Field Potention) data sampled on total 6 rats in resting with sniffing and of iEEG data on total 10 patients in quiet wakefulness. The comparison of alpha-theta power is done between the inter-ictal groups and control groups. It is concluded that the inter-ictal SWs can disrupt the power of alpha-theta oscillations, leading to the decreased power after SW. Because the alpha-theta oscillations are related with the cognition, it is estimated that the inter-ictal SWs can negatively affecte the cognitive function during the inter-ictal dynamics, although the alpha-theta power will be recoverable in some days after injections, even exceed over the power level before injections.