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Updated: Jun 6, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
New reconstruction algorithm, distance dependent exact, with reduced statistical α error, dedicated to emission
Christian Jeanguillaume1, Richard Simonnet, Hervé Rakotonirina
1LISA : Laboratoire d'ingénierie des systèmes automatisés. Université d'Angers 62 Avenue Notre Dame du Lac 49000 France.
Abstract:
SPECT (single photon emission computerized tomography) is physically one of the worst medical imaging modalities. Despite a considerable and still increasing medical impact, its spatial resolution (beyond 1 cm) and its sensitivity (less than 10(-4)) are both awful. This situation is mainly due to the use of a thin parallel hole collimator. In addition the application of the unfitted radon-transform worsens the figure.
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