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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

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Standardization proposal to pharmaceutical compounded forms elaboration - information system.

Sybelle S K Okuyama¹, Claudia M C Moro

¹Health Technology Postgraduate Program - Pontifical Catholic University of Paraná (PUCPR), Brazil. sybelle.s@pucpr.br

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|November 25, 2010

Summary

This summary is machine-generated.

Standardizing pharmaceutical compounding is crucial for quality. This study proposes a flowchart standard and an information system to guide pharmacists in preparing semi-solid and liquid external medications, ensuring accurate formulations.

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Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

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Last Updated: Jun 6, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Area of Science:

Pharmaceutical Sciences
Compounding Pharmacy
Drug Formulation

Background:

Compounded preparations lack standardization, impacting quality.
Existing information systems do not support compounding elaboration.
Standardization is key for successful pharmaceutical compounding systems.

Purpose of the Study:

To propose a standardization for pharmaceutical semi-solid and liquid external use forms preparation.
To develop an information system to aid compounding pharmacists in decision-making and active ingredient selection.

Main Methods:

Conducted a study on drug preparation characteristics across different establishments.
Developed standardized flowcharts detailing sequence, features, and restrictions for drug elaboration.
Validated flowcharts using the Delphi Method with compounding pharmacy specialists.
Created an information system based on the proposed standard and defined variables (e.g., active's name, pH, compatibilities).

Main Results:

A comprehensive standardization proposal for pharmaceutical compounding was developed.
An information system was successfully created to support pharmacists' decisions.
The system demonstrated effectiveness by providing correct action plans for six common, previously misformulated prescriptions.

Conclusions:

The proposed standardization and information system significantly improve the accuracy of compounded preparations.
Implementation of this standard can enhance quality control and reduce errors in pharmaceutical compounding.
The developed system serves as a valuable tool for compounding pharmacists, aiding in complex formulation processes.