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Recognition of novel glycolipid antigens from smooth variants of Mycobacterium tuberculosis
D E Minnikin1, M Ridell, R C Bolton
1Department of Chemistry, The University, Newcastle-upon-Tyne, UK.
FEMS Microbiology Letters
|January 15, 1990
Abstract:
A major polar and three minor slightly less polar glycolipids were identified in extracts of two smooth (Canetti) strains of Mycobacterium tuberculosis. Immunostaining on thin-layer chromatograms and enzyme-linked immunosorbent assay (ELISA) of purified lipids demonstrated that the major and the two most polar of the minor glycolipids are potent antigens, reacting with homologous antisera and also with that raised against the type strain (H37Rv).